Inbred Strains of Laboratory Animals: Superior to Outbred Mice?
نویسندگان
چکیده
منابع مشابه
Susceptibility of inbred and outbred mouse strains to Sendai virus and prevalence of infection in laboratory rodents.
Sendai virus is one of the more prevalent and serious virus infections of rodents. Infection was found in 66% of the mouse, 63% of the rat, 83% of the hamster, and 44% of the guinea pig colonies examined. Twenty-four inbred and outbred strains of mice were tested for their sensitivity to lethal Sendai virus infection. The 129/J mice tested were approximately 25,000-fold more sensitive than SJL/...
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The study of genetic variance in opioid receptor antagonism of sucrose and other forms of sweet intake has been limited to reductions in sweet intake in mice that are opioid receptor-deficient or lacking either pre-pro-enkephalin or beta-endorphin. Marked genetic variance in inbred mouse strains has been observed for sucrose intake across a wide array of concentrations in terms of sensitivity, ...
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Inbred strains of mice such as C57BL and BALB/c are more widely used in published work than outbred stocks of mice such as ICR and CD-1. In contrast, outbred stocks of rats such as Wistar and Sprague-Dawley are more widely used than inbred strains such as F344 and LEW. The properties of inbred and outbred mice and rats are briefly reviewed, and it is concluded that, with some exceptions, there ...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1995
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/87.12.933